The main focus of the research carried out in our laboratory is to understand the influence of immunity on the within-host dynamics and evolution of infectious diseases. We use mathematical models to understand the kinetics, pathways of differentiation and efficiency of immune responses (in particular, CD8 T cell response) to intracellular pathogens such Lymphocytic choriomeningitis virus (LCMV), Influenza, Listeria monocytogenes (LM), Simian and Human immunodeficiency viruses (SIV and HIV). We have been developing and refining methods to quantify rates of production and death of immune cells and rates of migration of immune cells to different organs in mice and humans from experimental data. We also have been investigating how pathogens evolve within (and between) hosts to avoid immunity and how such evolutionary interplay between the pathogen and the host may result in disease. Particular topics we are currently interested in include “Kinetics of CD8 T cell responses to intracellular pathogens”, “Quantifying turnover of immune cells in vitro and in vivo”, “Viral evolution within hosts in response to immunity on the example of HIV and SIV”.

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