Dr. Tim Sparer
Office: F417 Walters Life Sciences
Lab: A403 Walters Life Sciences
There are two main areas of research in my lab.
Viral Chemokines and CMV Pathogenesis
Chemokines are small chemotactic cytokines that are important in controlling leukocyte trafficking during innate, inflammatory, and adaptive immune responses. My work focuses on both human and murine cytomegaloviruses, investigating how these viruses use viral/host chemokines to alter the trafficking of immune cells for the viruses' benefit.
Chemokine Receptors and Cancers
Chemokines and their receptors normally function in inflammatory, developmental, and homeostatic processes. Deregulation of this system is associated with the development of cancers and metastasis. Constitutively active chemokine receptor, CXCR2, continually induce a signal within a cell in the absence of ligand can lead to cellular transformation, the first steps in cancer development. We are currently investigating the important residues of CXCR2 responsible for activation. These discoveries may lead to the development of drugs to shutoff CXCR2s thus providing doctors with another weapon in their arsenal to treat melanomas or to decrease their metastatic potential.
To view a brief video about my research, click here.
More information, see lab page.
- B.A., 1989, Northwestern University
- Ph.D., 1996, Emory University
- Postdoctoral Fellow, 1996-1999, Imperial College, London, UK
- Postdoctoral Fellow, 1999-2003, Stanford University