Dr. Todd Reynolds
Office: F321 Walters Life Sciences
Lab: B314 Walters Life Sciences
The Reynolds lab focuses on the roles of the phospholipids phosphatidylethanolamine (PE) and phosphatidylserine (PS) in regulating virulence, cell wall composition, and biofilm formation in the pathogenic yeasts Candida albicans and Candida glabrata (most prevelant human fungal pathogens), and the nonpathogenic yeast Saccharomyces cerevisiae (a powerful single-celled eukaryotic genetic model organism). Projects include: 1) Validating unique fungal lipid synthesis enzymes and/or transcriptional regulators as potential antifungal drug targets. In C. albicans, the Cho1p PS synthase is necessary for disease, and is therefore a good antivirulence drug target that is conserved throughout fungi, but is not found in mammals. In Candida glabrata the Opi1p transcription factor, which is unique to fungi, is necessary for viability, and therefore may be a good drug target. 2) Discovering the roles of PS and PE in regulating signal transduction cascades that affect the fungal cell wall (an important factor in fungal virulence). We are using transcriptomic, lipidomic, and cell wall carbohydrate analyses along with genetic and cell biology approaches to address this question in fungi. 3) Elucidating how PS, PE, and associated membrane proteins on the plasma membrane and endosomal protein sorting compartment regulate biofilm formation in fungi.
For more information click here
- B.S., 1993, Western Kentucky University
- Ph.D., 1999, Vanderbilt University
- Postdoctoral Fellow, 1999-2003, Whitehead Institute